Prayer for Depression:Depression is more than just sadness. It’s a deep and lingering heaviness that often drains joy, distorts thoughts, and darkens even the brightest moments. It can leave people feeling isolated, ashamed, exhausted, and hopeless. For believers, this burden may feel even heavier when faith seems dim or prayers feel unheard. But God sees every tear, hears every silent cry, and walks with those who are hurting—even when they don’t feel His presence.
40 Powerful Prayer for Depression is a collection of short, heartfelt prayers based on Scripture. These prayers are not magic formulas, but simple expressions of faith, honesty, and hope for those walking through depression. Whether you’re praying for yourself or someone you love, let these words be a guide to connect with the God who heals, restores, and strengthens the brokenhearted.
This resource repeats the title 40 Powerful Prayer for Depression throughout, reminding us again and again that we are not alone in the struggle—and there is hope.
Prayer for Depression
1. Prayer When Depression Feels Heavy
“Come to me, all you who are weary and burdened, and I will give you rest.”
—Matthew 11:28
Jesus, this burden is too heavy for me. I feel tired and empty. Please give me rest in my soul. Carry me when I cannot walk.
2. Prayer for a Mind at Peace
“You will keep in perfect peace those whose minds are steadfast, because they trust in you.”
—Isaiah 26:3
Lord, my thoughts are anxious and restless. Calm my mind and give me peace. Help me trust You even when I feel overwhelmed.
3. Prayer for Strength to Face the Day
“The Lord is my strength and my shield; my heart trusts in him, and he helps me.”
—Psalm 28:7
Father, today feels impossible. Please be my strength. Help me to take even one step forward. I trust You to help me through.
4. Prayer for God’s Presence in the Darkness
“Even though I walk through the valley of the shadow of death, I will fear no evil, for you are with me.”
—Psalm 23:4
Lord, the darkness feels too deep. But I choose to believe You are here with me. Walk with me through this valley.
5. Prayer for Hope to Return
“Why, my soul, are you downcast? Why so disturbed within me? Put your hope in God…”
—Psalm 42:11
God, I feel hopeless. Remind my soul to hope in You again. Let the light of Your promises rise in my heart.
6. Prayer for Comfort in Isolation
“The Lord is close to the brokenhearted and saves those who are crushed in spirit.”
—Psalm 34:18
Father, I feel so alone. Please come close to me. Hold me when I feel crushed and remind me that I am not forgotten.
7. Prayer for a Gentle Heart
“A bruised reed he will not break, and a smoldering wick he will not snuff out.”
—Isaiah 42:3
Jesus, I feel fragile. Thank You for Your gentleness. Handle my heart with care and breathe life into what feels like dying hope.
8. Prayer for Release from Guilt
“Therefore, there is now no condemnation for those who are in Christ Jesus.”
—Romans 8:1
God, help me release the guilt I carry. Remind me that in You, I am not condemned. Let me rest in Your forgiveness.
9. Prayer When You Feel Numb
“He heals the brokenhearted and binds up their wounds.”
—Psalm 147:3
Lord, I feel nothing. Numb and disconnected. Please heal my broken heart. Touch the places that have shut down and awaken them with Your love.
10. Prayer for Courage to Keep Living
“I have come that they may have life, and have it to the full.”
—John 10:10
Jesus, help me choose life today. Remind me that You came to give me life worth living. Give me the courage to keep going.
11. Prayer When You Feel Forgotten
“Can a mother forget the baby at her breast…? Though she may forget, I will not forget you!”
—Isaiah 49:15
Lord, it feels like no one sees me or understands what I’m going through. Please remind me that You have not forgotten me.
12. Prayer for Peace in the Chaos
“God is our refuge and strength, an ever-present help in trouble.”
—Psalm 46:1
Father, I feel surrounded by turmoil. Be my refuge. Cover me with Your peace and help me rest in Your presence.
13. Prayer for a Gentle Morning
“Because of the Lord’s great love we are not consumed… his compassions never fail. They are new every morning.”
—Lamentations 3:22-23
Lord, let today begin gently. Bring fresh compassion into this new morning. I need Your mercy just to begin.
14. Prayer for Strength to Reach Out
“Carry each other’s burdens, and in this way you will fulfill the law of Christ.”
—Galatians 6:2
Help me, Lord, to ask for help. Let me not suffer in silence. Send someone who will walk with me through this.
SEE ALSO: 40 Short Powerful Prayer to Comfort a Grieving Friend
15. Prayer to Silence Negative Thoughts
“We take captive every thought to make it obedient to Christ.”
—2 Corinthians 10:5
Jesus, my mind is full of lies and darkness. Please take every thought captive. Replace the lies with Your truth.
16. Prayer for God to Light the Way
“Your word is a lamp for my feet, a light on my path.”
—Psalm 119:105
Lord, I don’t know where to go from here. Shine Your light on my path and guide me step by step.
17. Prayer for Restful Sleep
“In peace I will lie down and sleep, for you alone, Lord, make me dwell in safety.”
—Psalm 4:8
God, my nights are full of worry and wakefulness. Please give me peace and allow me to sleep in Your safety.
18. Prayer for Healing from Past Wounds
“Forget the former things; do not dwell on the past. See, I am doing a new thing!”
—Isaiah 43:18-19
Lord, the past still hurts. Please help me to let go and trust that You are doing something new in my life.
19. Prayer When You Feel Useless
“For we are God’s handiwork, created in Christ Jesus to do good works…”
—Ephesians 2:10
God, I feel like I have no purpose. Remind me that I am Your creation, made for something meaningful.
20. Prayer to Remember Your Identity
“See what great love the Father has lavished on us, that we should be called children of God!”
—1 John 3:1
Father, I feel lost and broken. Remind me that I am still Your child—loved, chosen, and known by You.
21. Prayer for the Will to Keep Going
“Let us not become weary in doing good, for at the proper time we will reap a harvest…”
—Galatians 6:9
Lord, I’m tired of trying. Please give me the will to keep moving forward. Don’t let me give up.
22. Prayer to Dismiss Shame
“Those who look to him are radiant; their faces are never covered with shame.”
—Psalm 34:5
Jesus, I feel ashamed of how I feel. But You don’t shame me. Let Your love lift my head.
23. Prayer for Renewed Strength
“Those who hope in the Lord will renew their strength…”
—Isaiah 40:31
God, renew my strength. My energy is gone. Let hope rise in me again like wings on the wind.
24. Prayer for God’s Faithfulness
“The Lord is faithful to all his promises and loving toward all he has made.”
—Psalm 145:13
Father, I feel forgotten. But Your Word says You are faithful. Help me to believe that You will keep Your promises.
25. Prayer for Joy to Return
“Weeping may stay for the night, but rejoicing comes in the morning.”
—Psalm 30:5
Lord, joy feels far away. Please let the morning of rejoicing come soon. Let my heart laugh again.
26. Prayer When Hope is Fading
“May the God of hope fill you with all joy and peace as you trust in him…”
—Romans 15:13
Jesus, restore my hope. Let peace and joy return as I place my trust in You again.
27. Prayer for Purpose in the Pain
“And we know that in all things God works for the good of those who love him…”
—Romans 8:28
God, I can’t see any good in this. But I trust You are working. Bring purpose out of this pain.
28. Prayer to Feel God’s Love
“Nothing can separate us from the love of God that is in Christ Jesus our Lord.”
—Romans 8:39
Lord, I feel unlovable. Wrap me in Your love and show me that nothing—not even depression—can take it away.
29. Prayer for a New Beginning
“If anyone is in Christ, the new creation has come: The old has gone, the new is here!”
—2 Corinthians 5:17
Jesus, make me new. Let me rise from this place with fresh life and hope in You.
30. Prayer to Feel God’s Nearness
“The Lord your God is with you, the Mighty Warrior who saves…”
—Zephaniah 3:17
God, be close. Let me feel You near, fighting for me, and singing over me with love.
31. Prayer for Calm in the Storm
“He got up, rebuked the wind and said to the waves, ‘Quiet! Be still!’”
—Mark 4:39
Jesus, speak peace over the storm inside me. Quiet my heart and still the raging fear.
32. Prayer for Wisdom in the Struggle
“If any of you lacks wisdom, you should ask God…”
—James 1:5
Lord, I don’t know how to walk through this. Please give me wisdom to know what to do and where to turn.
33. Prayer When You Feel Worthless
“You are precious and honored in my sight… and I love you.”
—Isaiah 43:4
God, I feel worthless. Please remind me that I am precious to You. Let Your love speak louder than my doubt.
34. Prayer to Be Seen
“You are the God who sees me…”
—Genesis 16:13
Father, I feel invisible. But You see me. You know me. Let me feel seen and loved by You today.
35. Prayer When You Feel Exhausted
“He gives strength to the weary and increases the power of the weak.”
—Isaiah 40:29
Lord, I am so tired. Please give me the strength I don’t have. Be my energy today.
36. Prayer to Take the Next Step
“Your word is a lamp for my feet, a light on my path.”
—Psalm 119:105
God, show me the next step. I can’t plan ahead, but I trust You for today. Light my path.
37. Prayer for God’s Peace to Guard Your Heart
“The peace of God… will guard your hearts and your minds in Christ Jesus.”
—Philippians 4:7
Lord, guard my heart. Guard my mind. Let Your peace protect me from every lie and fear.
38. Prayer for God’s Voice Above the Noise
“My sheep listen to my voice; I know them, and they follow me.”
—John 10:27
Jesus, the noise in my mind is loud. Help me to hear Your voice above it all. Speak peace and truth.
39. Prayer to Be Carried by Grace
“My grace is sufficient for you, for my power is made perfect in weakness.”
—2 Corinthians 12:9
Lord, I am weak. But Your grace is enough. Carry me when I can’t stand on my own.
40. Prayer for Healing and Wholeness
“He has sent me to bind up the brokenhearted, to proclaim freedom for the captives…”
—Isaiah 61:1
Jesus, come and heal me. Bind up my broken heart. Set me free from this heavy prison. Make me whole again.
Depression may feel like a lifelong weight, but it does not have the final word. God sees every tear and knows every silent ache. He never turns away from the brokenhearted. These 40 Powerful Prayer for Depression are meant to be tools—gentle words to help you cry out when you don’t know what to say, Scripture to hold onto when your own strength runs out.
You are not weak because you’re struggling. You are brave because you keep showing up. God’s love does not fade when you feel low. His grace does not run out. His promises are true, even in the darkest valley.
Keep praying. Keep breathing. Keep holding on. Let 40 Powerful Prayer for Depression remind you again and again: You are loved. You are not alone. And there is always hope in Jesus Christ.
